Balanced supply of essential nutrient is one of the most important factor for increasing rice yield. Hence, knowledge of interaction of N with other nutrients are very important for improving fertilizer use efficiency and consequently increasing rice yield.  A Field experiment was carried out at Rice Research and Training Center experimental farm during 2016 and 2017 seasons to assess the influence of different combinations of N, P, K and Zn fertilizer on yield of Sakha105 rice variety, its attributes, NPK uptake, N-recovery efficiency and agronomic nitrogen use efficiency. The fertilizer combinations were: (1) control, (2) N, (3) N + P, (4) N + K, (5) N + Zn, (6) N + P + Zn, (7) N +K + Zn, (8) N + P + K, and (9) N + P + K + Zn. Yield and yield attributes of Sakha 105 rice cultivar were significantly affected by different combinations of N, P, K and Zn fertilizer. The NPKZn treatment resulted in the highest grain yield, number of panicles hill^-1, number of filled grain panicle^-1 andlowest sterility percentage compared with the control. In addition, the uptake of N, P and K varied significantly by the application of different combinations of N, P, K and Zn fertilizer in both growing seasons. Nitrogen recovery efficiency % varied significantly with different fertilizers and ranged from 24.01 to 41.39% and from 26.08 to 43.99% in 2016 and 2017, respectively. The application of different chemical fertilizers significantly increased the available soil NH₄⁺ content and available soil P concentration at different days after transplanting compared with the control. The study suggests that balance nutrient application using N, P, K and Zn fertilizers is a key management strategy for sustaining soil fertility and therefore increasing rice yield.