A pot experiment was conducted in winter season of 2015-2016 at the experimental farm, Faculty of Agriculture, Mansoura University, Dakahlia Governorate, Egypt to study the interaction effect between some kinds of organic acids (Humic acid 200 mg.L-1, Ascrobic acid, Salicylic acid and Glycine at rate of 330 mg.L-1), and irrigation water having different salinity levels (0.4, 2.12, 4.82 and 9.11 dS.m-1) on wheat (Triticum aestivum l.) Suds 12 variety grown on clayey soil. The experimental design was split plot design with two factors in three replicates .The obtained results can be summarized as follow ; the dry weight of grain (g.pot-1) was decreased with increasing water salinity levels from 0.4 dS.m-1 (tap water) till 9.11  dS.m-1 by 0.2.12; 7.73 and 12.34 compared to control (tap water, 0.4 dS.m-1). It could be arranged the organic acids for increasing straw dry weight in the following order Sa> Aa> Ga> Ha. Whereas , it could be arranged the organic acids for 100 grains weight in the following order Sa> Aa> Ga> Ha. Also, it was found that foliar application of Ga (330 mg/l) under normal conditions and all studied levels of salinity gave  an increase in plant height compared to the other organic acids. The majority data of the studied nutrients content were not significantly affected by all studied factors and/or salinity levels except for Na and N content in straw and P content in grain. There was a decreasing effect in nutrients content due to increasing salinity levels except for sodium content in both straw and grain. A significant increase in Na content under the different studied salinity levels was found in both straw and grain of wheat plant, where the highest Na% in straw was 2.04% (S3A2) which was gained with ascorbic acid with salinity level=9.11 dS.m-1. Whereas, the highest mean value of Na% in grain was 0.24% (S3A3). The highest N content in straw was gained with Sa (2.38%), whereas, it reached 3.778% in grain using Aa (ascorbic acid with 330 mg/L). The highest mean value of P% in grain was 0.639% (S0A2) which was obtained with the treatment of (Aa) ascorbic acid + (tap water) salinity level of 0.4 dS.m-1 .The highest mean value of P% in straw was 0.065% (S0A2). So the highest accumulation of P was gained with the treatment of (Aa) ascorbic acid + (tap water) salinity level of 0.4 dS.m-1, but the highest accumulation of K was gained with the treatment of Ga (glycine acid treatment)+  salinity level of 9.11 dS.m-1. Finally, it is recommended to use Sa (salicylic acid ) and/ or Ga (glycine acid) with concentration of 330 ppm which may increase the ability of wheat plant to grow efficiently and successfully under the stressed saline conditions