Two field experiments were carried out at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, Egypt during the two successive seasons of 2014/2015 and 2015/2016. The objectives of this research were: (i) to study the effect of irrigation regime using tow irrigation levels (40% and 60%) of soil moisture depletion on wheat grain yield; (ii) to evaluate the growth, yield and N use efficiency of wheat as affected by different rates of N fertilization. The experimental used design was split split plot design with three replicates. Irrigation regimes I₁ (irrigated at 40% depletion) and I₂ irrigated at 60% depletion were assigned in the main plots.  Three nitrogen rates i.e. zero, 50, and 75 kg N fed^-1 in the sub plots namely N₀, N₅₀, and N₇₅ and two doses of nitrogen i.e D₁ one time and D₂ tow times Results showed that irrigation at 40% depletion significantly increased grain yield by 6.03, 5.5% and straw yield by 7.8, 9.1% compared to irrigation at 60% depletion during the tow growing seasons respectively. The highest grain yield value of 3107.43, 2955.50 kg fed^-1 was obtained with   I₁N₇₅D₂ treatment, while the lowest one was 2265.05, 2174.05 kg fed^-1 with I₂N₅₀D_1­ in the 1^st and 2^nd seasons respectively. Also irrigation at 40% depletion resulted in the higher amount of irrigation water to be 1810, 1920 m³ fed^-1 distributed on 5 irrigations while it was 1460, 1600 m³ fed^-1 irrigated at 60% depletion distributed on 4 irrigations during the 1^st and 2^nd seasons respectively. The highest consumptive water use was obtained under irrigation at 40% depletion i.e 38.53, 39.6 cm while the lowest 32.48, 32.58 cm obtained from irrigation at 60% depletion in the 1^st and 2^nd seasons respectively.  Increasing nitrogen rates up to 75 kg N fed^-1 (N₇₅) significantly increased grain yield by 234.4%, 119.0% and 218.5%, 111.2 % as compared to control N_0;  N₅₀ treatments in the 1^st and 2^nd seasons respectively. Also, increased straw yield by 192.9%, 111.4% and 182.4%, 111.6% as compared to N_0;  N₅₀ treatments in the 1^st and 2^nd seasons respectively. Nitrogen use efficiency (NUE) increased with increasing water applied. It was 0, 42.07, 24.23 and 0, 31.74, 17.32 for N₀, N₅₀ and N₇₅ on the 1^st and 2^nd seasons respectively, results showed that increasing the applied N-rate decrease the NUE since the highest value was obtained with N₅₀ and the lowest one obtained with N₇₅. The highest water productivity (WP) of 2.20, 2.4 kg m^-3 was obtained with I₂N₇₅D₂ treatment during 1^st and 2^nd seasons respectively. Therefore, it could be recommended that irrigate wheat at 60% depletion in north Nile Delta soils to save water of about 320 m³