The efficacy of six pesticides belonging to different chemical groups namely (Neomyl 90% SP, Agrinate 24% SL, Mesurol 2% RB, Metarol 5% EG, Biogard 6.5% WP and Cranch 10% Sp) against the glassy clover snail M. cartusiana with various concentration and applications under laboratory and field conditions. Results showed that, under laboratory conditions the cumulative mortality percentage increases with the increase in the time of exposure to the pesticide, as well as the concentration rate. Data revealed that, Neomyl, Agrinate, Metarol and Mesurol were the most effective while Cranch and Biogard were the lowest. Regarding field trial, results revealed that, the efficacy of ready pellet baits was increased when applied by hand sowing than in piles on plastic pieces as in Metarol and Mesroul. Conversely, Neomyl and Agrinate exhibited the highest reduction percentage when applied as poisonous bait (piles on plastic pieces) than spray application. In concerning to Crunch and Biogard they show weak efficacy whether applied by poisonous baits or spraying