The efficacy of five synthetic pyrethroids (Fenvalerate, esfenvalerate, cyfluthrin, fenpropathrin and deltamethrin), one insect growth regulator (tebufenozide) and the Juvenile hormone mimic (pyriperoxfen) were tested on 4^th instar larvae of S. littoralis. Tests were carried out on larvae of susceptible and field strains collected from Behera, Dakahleia, Gharbeia, Kafr-El-Sheikh and Sharkeia governorates using dipping technique. Field strain were collected and tested before and after spraying programs of different Governorates. Obtained data in general, indicated that the activity of the tested compounds in ascending order, were pyriperoxyfen, tebufenazide, fenvalerate, esfenvalerate, cyfluthrin, Fenpropathrin and deltamethrin. The biochemical studies on the tested strains after spraying program indicated variable activities in phosphatases (AlkP and AcP) and in carbohydrate hydrolyzing enzymes (amylase, trehalase and invertase).