The effect of 1/4 LDSO oral administration of herbicide "Machete" daily for S
weeks on body weight and haematological parameters of albino rats including
R.B.C.s, W.B.C.s, haemoglobin and packed cell volume were investigated. The
herbicide caused a significant decrease in body weight and a slightly increase in
W.B.C.s while red blood cells, haemoglobin and packed cells volume progressively
insignificantly decreased. Histological Changes of spleens W8re shown in the form of
lymphoid depletion and hyperplasia in the white pulps, while the red one and
sinusoids were hyperemic. However, it was found that the use of sublethal doses of herbicides
"Machete" has greatly affected the blood picture and spleen tissue of rats.