Sesame (Sesamum indicum L.) crop considers as one of the important oilseed crops in the world. Effectiveness of ten selected insecticides [Vertimec 1.8% EC, Agrin 6.5% WP, Thiovit 80% WG, Spinosad 48% SC, Evisect 50% SP, Match 5% EC , Pestban 48% EC, Dolf 5% EC , Lannate 90% SP and Proclaim 5% SG] against Antigastra catalaunalis, Spodoptera exigua and leafhoppers was examined. This study was carried out in farmer's field at New Valley, Egypt during 2021. The recommended concentrations for each insecticidal product were tested against A. catalaunalis, S. exigua and leafhoppers. The percentages of mortality were recorded after 3, 7, 14, 21 and 28 days. In case of A. catalaunalis, Spinosad 48% SC and Dolf 5% EC were found to be the most effective compounds. While, Pestban 48% EC and Spinosad 48% SC were found to be most effective compounds against S. exigua. On the other side, Dolf 5% EC and Match 5% EC were found more effective against leafhoppers than other chemical products. These alternative insecticides could be recommended to use against A. catalaunalis, S. exigua and leafhoppers in sesame crop and elsewhere.