Aphids, particularly Aphis gossypii Glov., is one of the most-important-pests in squash farms, caused serious losses by sucking plant sap in addition to plant viruses' transmission such as Papaya ringspot virus-W (PRSV-W). The current work conducted to study of the effect of various-systemic-insecticides and mineral-oil against melon-aphid, “Aphis gossypii" and its ability on transmissions of non-persistent-viruses under laboratory conditions. Data obtained showed that the “flonicamid" and “pymetrozine" recorded significantly-reduction in virus-acquisition and inoculations when compared-with control “also" reductions were compared-with mineral-oil applications. On-other-hand, data obtained of insecticide-residues activity and KZ-oil on “PRSV" transmission-rate by “A. gossypii" revealed that flonicamid had significantly higher persistence up to 12 days followed by pymetrozine. The mineral oil experienced a significant increase in transmission rate as its efficacy decreased dramatically on the eighth transmission and twelfth days.