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238856

HAZARD ASSESSMENT OF MANCOZEB FUNGICIDE AFTER IN VIVO EXPOSURE: HEMATOLOGIC, CYTOGENETIC, AND ENDOCRINE TOXIC IMPACTS

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Last updated: 22 Jan 2023

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Abstract

The hemato-cytogenetic and endocrine toxic effects of mancozeb (technical and formulated) have been studied in male Wistar rats. Sublethal doses administered orally for 28 day resulted in several alterations. Notable significant changes in organ weight ratio were recorded where the technical showed decreasing pattern, while the formulated showed increasing trend indicating alteraion of the physiological state of the exposed animals either in the whole body weight or in the function of internal organs. In the hemato-toxicologic context, blood indices were affected by exposure where technical compound exhibited increasing pattern of red and white blood cells while the formulated caused decreasing in red blood cells although the erythrocytes indices showed significant elevation after all dose regimens. Furthermore, technical mancozeb at 500 mg/kg resulted in slight significant increase (p < 0.01) in the frequency of micronuclei in the polychromatic erythrocytes of bone marrow (10±0.816), while the same dose of the formulated induced a highly significant increase (p < 0.001) in the frequency of micronuclei (14±0.816) when compared with the negative control raising concern for its mutagenic potential.   Additionally, ultrastructural changes of the thyroid gland were recorded after exposure to both forms of the compound. It may be suggested that hormonal imbalance is the causative factor related to the thyroid follicular hyperplasia. In a conclusion mancozeb; particularly the formulated form, is suggested to be of toxicological concern due to a potential hazard posed to the effect on thyroid gland and its genotoxic effects. Further studies should delineate the respective pathways of mancozeb intoxication.

DOI

10.21608/jppp.2005.238856

Keywords

fungicide, Mancozeb, toxicity, Micronuclei, THYROID

Authors

First Name

Salwa

Last Name

Abd-Allah

MiddleName

M.

Affiliation

Central Agricultural Pesticides Laboratory, ARC, Alexandria, Egypt

Email

sabdallah@link.net

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Orcid

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First Name

Safaa

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Central Agricultural Pesticides Laboratory, ARC, Alexandria, Egypt

Email

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City

-

Orcid

-

First Name

Madiha

Last Name

Talha

MiddleName

M.

Affiliation

Central Agricultural Pesticides Laboratory, ARC, Alexandria, Egypt

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-

City

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Orcid

-

Volume

30

Article Issue

3

Related Issue

34369

Issue Date

2005-03-01

Receive Date

2022-05-23

Publish Date

2005-03-01

Page Start

1,701

Page End

1,716

Print ISSN

2090-3677

Online ISSN

2090-3758

Link

https://jppp.journals.ekb.eg/article_238856.html

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https://jppp.journals.ekb.eg/service?article_code=238856

Order

7

Type

Original Article

Type Code

888

Publication Type

Journal

Publication Title

Journal of Plant Protection and Pathology

Publication Link

https://jppp.journals.ekb.eg/

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Article

Created At

22 Jan 2023