Laboratory feeding tests were carried out to determine the eff1cacy of four anticoagulant rodenticides, brodifacoum 0.001 %, flocuomafin 0.005%, coumatetralyl 0.0375% and chiorophacinone 0.005% baits against the house mice Mus muscuius and the ship rats Rattus rattus which were trapped from Etay El Baroud district El Sehera Governorate . “No- choice" feeding tests were carried out ¡n the laboratory. Results indicated that all anticoagulants caused complete mortality for rats of the two species. Brodifacoum killed all animals after a shorter time (3. 5 and 4.8 days) than ocoumafin (4.5 and 4.9 days) followed by coumatetralyl (5.13 and 6.1 days) and then chlorophacinone (5.17 and 6.4 days) for Rattus rattus and Mus musculus, respectively with less quantity of consumed bait. For mean time to death no significant differences were observed between sexes of the two species. All rats had decreased food consumption after the second day of treatment. In general, the results seemed that the entire tested compound showed good effect with the order being brodifacoum, followed by flocoumafin then coumatetralyl and cilorophacinone baits under laboratory conditions