Application of chemical compounds (i.e. Moncerin, Rhizolex T and Topsin M) and bee products (i.e. bee honey, propoils and royal jelly) were reduced growth of Ascosphaera apis (Chalk brood disease of honey bee) and Aspergillus flavus (stone brood disease of honey bee), compared with the control. Percentage of growth reduction to both pathogens was increased with increasing the rates of chemical compounds or bee products application. Meanwhile, application of chemical compounds were more effective than naturally products to reduction growth of A. apis and A. flavus. However, royal jelly as naturally products and topsin M as chemical compounds were the most effective to reduction growth of both pathogens. Application of both Rhizolex T or Moncerin as chemical compounds and propolis or bee honey as bee products were moderately effective.