The effect of the natural Infestation with certain sucking insects of aphids spp. , whiteflies , iassids and thrips on the gross chemical composition and epicutical lipids in leaves of two local globe artichoke cultivars , Cordoon and Hybrid c.vs ,grown at Shubramunt village in Giza Governcrate in the season , 2002 l 2003 , in order to protect the crop properties . The aphid population of some species was the highest number on leaves of both the cultivars during the tested season . followed by Bern/sia tabac ( Genn ) while Enrpcasca dea'pieris Poet: and Tfirips {abaci Lmn were the lowest one This is considered as the first record of this cultivars in Egypt Chemical analySis were made at the Centre? La .oratory cf Fac Of Agrlc , Ain Shah s Univ ,, Egypt , to evaluate the constituents and epicuticual lipids , the percent measurements of its fractions and the e‘fect of these sucking infestation The total nitrogen , reductng sugar , non-reducing sugar .total soluble sugar ,starch . protein , fats and moisture besides the epicuticuai lipids were determined in leaf samples collected at two intervals ranging from 2 weeks from each the two tested seasons The results showed that each reducrng , non—reducing sugars and total solubie sugars are positively affected the infestation with sucking insects as 36.17 , 19.26 , 28.80 respectively in leaf samptes of Cordoon cv. ‘v‘v'hile on Hybrid cv. it reduced completely ( 10 9'0 ) in leaf samples , An increase showed in total nitrogen and protein contents as 189 9'0 and 1.90 % respectively in infested leaf sample of Cordon but it decreased in Hybrid infested leaves as 364 9'5 and 3.67 % respectively . Fats decreased in both tested cultivars as 22.01 % and 18 68 % while starch and mosture increased each as 67.64 0/0 , 70.49 % for starch and 23.80 0/0 . 25 49 9t; for the second content , respectively for both the cultiva's ( all based on dry weight ). Furthermore , leaf sample were assayed for their specifc phenolic composnion ( Tannic acid ji when the analysts recorded decrement as 72,39 % , when: its percentage decreased from 0‘63 % in infested leaves ample to 0.045 ‘36 in uninfected leave sample for the Hybrid c v, Affected these sucking infestation . Also , there were a distinct differences in epicuticular lipids contents between both the infested and uninfected leaves of tie two tested cultivars . Some of these epicuticular lipids ; phospholipids ,monoglyceride , sterol , fatty actds , triglyceride and sterol ester markedly increased while diglyceride decreased and hydrocarbon were constant . in Cordoon infested leave sample whereas , in hybrid an increase recordec‘ in monoglyceride , diglyceride . sterol ester and hydrocarbon contents , a decrease showed in sterol but phospholipids , fatty acids and triglyceride were constant in both the infested and uninfected leaves sample. Therefore , it is recommended to control these sucking insects on g . artichoke plants using rules based on safe and modern | ,P M. programs from public health point of view .