The effect of diluted ethanolic extracts of five crude extracts of worrnseed (Artemisia cinae), lemongrass (Cymbopogon cflrates), senna (Cassia acutifoiia), geranium (Peiargonium graveoiens) and sweet basil (Ocimum basrircum) in addition to methomyl as standard molluscicide were tested for their mortality effects against Eobania vennicuiata, Theba pisana and Monacha obstructs snails at concentrations 25, 50, i5 and 100% and Biochemical studies were also conducted in vivo to determine the lower concentrations (5, 10. 25 and 50%) of the tested crude extracts and methomyl on the activity of ALT (Alanine Transaminase) and AST (Aspartate transaminase) as well as the total soluble protein in the three tested snails. The Eobania vennicuiata was highly affected by lemongrass. wonnseed and senna crude extracts but Theba pisana and Monacha obstructs were less sensitive. On the other hand, AST enzyme in E. vermicuieta was higher stimulated by all the tested crude extracts than methomyl. The effect of methomyl on the activity of AST enzyme in T. pisana and M. obstructs was nearly similar with the effects of the tested extracts. ALT enzyme was weakly affected different crude extracts in addition to methomyl. Total soluble protein was very sensitive in E. vermiouiata to senna extract and methomyl.