The seasonal dynamic of ixodid ticks and infection rate with Borreiia Sp. in ixodid ticks, human, domestic animals (camels, goats 8 sheep, dogs, cattle, and buffaloes), and pet animals (dogs) were investigated in El- Tal El:- kebeer, Esmaieliya governorate for 2 successive years from Mar. 2000 to Feb. 2002. The borrelial infection rate occurred in the tick population throughout the year. Spirochetes were detected in 3?.28% of the 1870 ticks examined. The highest percentage (p < 0.001), of infection with Borreiia Sp. in ticks were recorded in H. dromedarii (47.92%), followed by R. sanguineus (38.37%), B. annuiatus (32.5%), and H. excavatum (30.42%). The prevalence of infection rate with Borreiia Sp. in the females of each species was higher than males. The highest levels of infection with Borreiia in adult ticks were recorded in summer. Boneiia spirochete was detected in 35.79% of the blood samples (1900 samples) which were collected from man in Esmaieliya. governorate. Where, the maximum infection rates were recorded in July. The highest infection rate in blood smears which were collected from animals in Esmaieliya was recorded in camels (23.45%), followed by dogs (13.27%), goats 8. sheep (12.15%), cattle and buffaloes (10%). The changes in prevalence of Borrelia infection rate in the tick population were positively correlated with changes in antibody prevalence in man and animal hosts and with changes in the tick population density. Generally, the all studied events were low in winter and early spring and gradually increased to reach the highest levels in summer (maximum level in Aug.) and autumn.