In this work the effect of using some designed frames and its position in the hive, also the effect of wire gride for these designed frames on the production of bee venom throughout the period 2/4/2006 to 25/6/2006 were student . For this purpose sex types (A, B, C, D , E and F) of modern collector plates were designed. Modern collector frames A, and C (wire gride area were measuring 1125cm²), and the other 3 modern collector frames D, E and F (wire gride area were measuring 562 cm²). Modern collector frames (A and D) were placed on the top of the combs. B and E Frames were placed among of the hive combs frames (C and F) were placed under the combs. Eighteen honey bee colonies were processed for the work which divided into 2 groups of 9 colonies each. The 1^st group were used for the collector frames A , B and C. while the 2^nd group were used for the collector frames D, E and F. The bee venom device was applied daring the work for collecting the material as mentioned by (Mohanny, 2005). The collected bee venom was regularly weighted a cording to each frame of the hive. Also the dead bees was experimented colony counted for each. The statistical analysis showed that the area (1125cm²) collected big amounts of bee venom than the area of wire grids measuring (562cm²). Other wands it could be mentioned that the biggest area collected big amounts of the material in  experimented colonies. Type was observed to collect bee venom in big quantities more than the other types. On the other hand bees in this type was smaller in number than the other types.