The ovicidal activity  and latent toxicicity of  certain actinomycetes namely  Spinosad and chitin synthesis inhibitor Lufenuron were studied in the laboratory against the cotton leafwrom Spodoptera littoralis. The summarized results show that both toxicants possess a moderate ovicidal activity and  toxicicty to 2^nd and 4^th instars as a result to direct treatment. On the other hand both toxicants  induced drastic effect on  fecundity and fertility of adult moths.Also caused sever histological aberration of the ovarioles and reduced the total lipid, protein and carbohydrate of the ovaries of females resulted from treatment of pretreated as 4^th instar  larvae with the two toxicants.