Field experiments were carried out at Bahtim Agricultural Research Station Farm during the two successive wheat seasons (2004/05 and 2005/06) to study the effect of four NPK combinations on aphid and leafminer infestation of Gemiza 7 and 9 varieties in addition to study effects of these combinations on some agronomic characters. Increasing the nitrogen rate tended to increase aphid and leafminer   infestation. The best combinations were that of 70 and 75kgN/fed., low infestation   but produced the heaviest grain yield. Gemiza 9 exhibited longer periods to heading (94.5 days) and to maturity (146.5 days), more spikes 389.1/m² and heavier yield either of grains (20.4  ardab/fed.) or of straw (7.3 ton/fed.). While, Gemiza 7 exhibited taller plants (107.2 cm) and heavier 1000-grain weight (51.2 gm). The variety Gemiza 9 proved to be more tolerant against aphids, it harbored the highest numbers of colonies but in        the same time produced relatively a heavier grain yield. While the interaction between varieties and NPK rates affected significantly   the aphid and leafminer infestation, it had no effect on any of the varietal                traits undertaken in this study.