The present study was carried out at the apiary of Beekeeping Research Section at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, during 2005 and 2006 seasons. Sixty colonies were divided into three groups, twenty colonies each to compare among F₁-F₂ Italian and F₁-F₂ carniolan honey bees on brood rearing activity, propolis and pollen gathering, royal jelly secretion and honey yield production. The results indicated that the F₁ Italian hybrid performed larger areas of sealed workers brood than did F₁ Carniolan, F₂ Italian and F₂ Carniolan hybrid with averages of 1079.93, 792.76, 847.40 and 771.72 inch²/colony/month in the first year, and 929.08, 738.96, 794.95 and 756.79 inch²/colony/month, in the second one, respectively. In case of drone brood, F₁ Carniolan hybrid (11.00 & 9.90 inch²/colony/month) was higher than F₂ Carniolan (7.96 & 7.14), F₂ Italian (7.05 & 6.17) and F₁ Italian hybrid (6.86 & 5.11 inch²/colony/month) in the first and second year, respectively. Also, F₂ Italian hybrid collected the largest amount of propolis (8.40 & 6.95 g/colony) compared with F₂ Carniolan (7.77 & 5.99), F₁ Italian (7.56 & 6.63) and F₁ Carniolan (6.98 & 4.56 g/colony) in the first and second years. The largest amount of pollen was gathered during clover nectar flow followed by maize and broad bean for the four honeybee hybrids (F₁-F₂ Italian and F₁-F₂ Carniolan) in both seasons. Analysis of variance revealed highly significant difference in amount of gathering pollen between F₁ Italian and other hybrids on broad bean, Egyptian clover and maize plants during the first and second seasons. F₁ Carniolan hybrid secreted more natural royal jelly in the first and second seasons (17.40 & 18.50 g/colony) than F₁ Italian (14.5l & 15.40), F₂ Carniolan (13.00 & 14.20) and F₂ Italian (12.60 & 13.60 g/colony), respectively. Also, F₁ Carniolan honey bees gathered the largest amount of artificial royal jelly (106.00 & 115.60 g/colony) during the period from 15 April until 15 June compared with other honey bee hybrids; F₁ Italian (97.25 & 100.40), F₂ carniolan (93.40 & 100.00) and F₂ Italian (92.40 & 99.40 g/colony) in two tested seasons, respectively. Data revealed that F₁ Carniolan produced the highest honey yield (6.55 & 6.95 kg/colony) followed by F₂ carniolan (5.75 & 7.85), F₁ Italian (5.51 & 5.70) and F₂ Italian (4.55 & 4.95 kg/colony) at the end of clover blooming season, respectively. Also, at the end of cotton blooming season, the honey yield of F₁ Carniolan hybrid (8.50 & 8.53 kg/colony) was more than other honey bee hybrids during 2005 and 2006 seasons. From the current results, it could be concluded that the F₁ Italian honeybee performed larger areas of worker brood and greater amounts of propolis and pollen than F₁ Carniolan, F₂ Italian and F₂ Carniolan honeybee. By contrast, the F₁ Carniolan achieved larger areas of drone brood and produced greater amounts of royal jelly and clover and cotton honey yield than other honey bees hybrids.