Field and laboratory experiments   had been carried out to evaluate mechanical control and some treatments   against rodent pests at Assiut district.   The evaluation of mechanical control measures to reduce rodent population was studied in woodland area. The evaluation of three anticoagulant rodenticides was studied   to establish the integrated rodent pest management which has the least impact on ecosystem, in addition to study. The relative susceptibility of different anticoagulant rodenticides (Brodifacoum, Chlorophacinone and Bromadiolone). In general it was observed  reduction in rodent numbers after using the ploughing and brushing wood operations. Complete absence in rodent numbers was achieved during the first five months in ploughing and brushing woods operations. Whereas, the number of rodent was increased gradually .  Females of  Arvicanthis  niloticus(Desm.) were more tolerant to all rodenticides than males at different poisoned baits and different concentrations . The acceptance of rats to the poisoned bait considerably differed according to the type of baits, the chemical structure of rodenticides and its concentrations. Bromadiolone carried on crushed maize was most acceptance to rats, while Brodifacoum carried on sunflower was the lowest. Brodifacoum carried on wheat was the most effective while the lowest effective was recorded when Chlorophacinone carried on sorghum. Also the effectiveness of rodenticides for mortality time conversed with the rodent wide concentration  , Bromadiolone 0.005%  more effective than Bromadiolone 0.004%.