The aim of this investigation was protection the sugarcane breeding varieties from infestation with the pink  stem borer , S. creticaLed,at El-Sabahia Station , Alexandria . G 85-37variety (95 borers/100 plants) was more  susceptible to infestation with the pink stem borer in two seasons . Moreover G85-39 was the most resistance to this borer (24 borers /100 plants) in the same seasons. There were significantly among varieties value as susceptibility to infestation by S. cretica . The leaves weight of G85-37 variety was the highest recorded (1312 gm ) in weight leaves value in both seasons. On other hand, the Co214 (775gm  )was the least one  in same character. Stalks weight character was significantly lower among varieties in both seasons. The highest  total  soluble  solid (T.S.S) value  was  appointed in 1^st  season by G85-39 (20.67).While it was low by F153 (16.33)&(16.17) in both season respectively. During the  season 2006/2007, the evolution of 4 insecticides and 2bio-insects were done.  In the  third day the Dipel 2x  (B. th. krustaki  ) reduced the  population  of  S. cretica by 19.33% in first period time (three leaves stage)  and 16.67% in second period  (Harvest time ). While reduction % was 0.0 % by B. bassiana ( Bio fly) in both period. Lannate reduction percentage was more toxicity  (91%) than Carbaryl (80.67%)  in same period . In three leaves stage (1^st period test) the Profenofos was very effective at third  day (92.33) . Bio-insecticides were more toxic in last priod(21day) for test at two application periods In addition, Dipel 2x^® is more toxic than (Bio fly ^® ) . Organophosphours insecticides increased the sugarcane yield character than another tested insecticides. IT could be concluded that all tested insecticides could be used against S. cretica .Using chemical insecticides gave fast reduction of then Bio-insecticides which are safety and less pollution than chemical insecticides.