Four systemic fungicides used as seed dressings were evaluated against barley leaf stripe  disease caused by Drechslera graminea This evaluation was carried out at Gemmeiza Agric. Res. Station in 2006/07 and 2007/08 seasons to identify a suitable fungicide to control barley leaf stripe. Under laboratory conditions, the tested fungicides had not phytotoxic effects on seed germination of Giza123 cultivar, since  germination % of seed ranged from 98.32 to 98.83 %. Under field conditions, no significant differences were found between the fungicides Tetraconazole ( Bremis) and  Diniconazole( sumi-8) in controlling the disease. Tetraconazole (2 cm/kg seed) , Diniconazole (1.5 cm/kg seed) and Teboconazole (1.2cm/kg seed) provided the  best  efficacy % of barley leaf stripe control releasing 96.29, 96.19 and 96.06 % efficacy, respectively. On the other hand , Semiconazole (1 gm/kg seed) showed  the lowest efficacy % in this respect(87.83%, ) . Grain yield expressed as spike weight and grain yield /m² was associated with fungicide efficacy. Tetraconazole (Bremis, 2.5%) showed the highest average of spike weight and grain yield /m² (4.98 and 258.50 gm, respectively ), while, Semiconazole (sunlit) showed the lowest average (3.83 and 187.46 gm, respectively).High correlation was found between efficacy of fungicides and both of increase % of spike weight (r = 0.9793) and Increase % of grain weight /m² (r = 0.9999).