The major aim of this work was to examine the effect of some artificial diet on brood rearing in three hybrids of honeybees. Four substitutes were used throw the experiments. In mostly the Craniolan hybrid recorded open (1037.70) and (946.98) brood more than the other hybrids on the other hand the highest open and close brood were recorded in summer at all hybrids. The results showed that, the results proved that the best hybrid is the Carniolan and that the best times are summer. Results showed that the opened and sealed brood rearing cells for the three hybrids had the highest value during autumn for the Craniolan hybrid (906.08 cells) followed by the buckfast (649.58 cells). While, the lowest value was recorded for the Italian hybrid (486.18 cells). During spring season, the highest value of the opened and sealed cells was recorded for the Craniolan hybrid (980.13 cells) followed by the buckfast (563.77 cells).