Land mollusks are significant an economical pest invading diver's flora in Egypt. In the light of this trial, Evaluated the efficiency of chemical compounds as metaldehyde, methomyl and copper sulfate against two land snail's species as the chocolate-band snail, Eobania vermiculata and the glassy clover snail, Monacha obstructa related to families, Helicidae and Hygromiidae was inquired. The findings showed that metaldehyde was the most lethal complex against M. obstructa and E. vermiculata came after methomyl and copper sulfate through seven days after that, the values of lethal concentrations 50 were (1.03, 1.80 and 19.70 %) and (1.60, 9.18 and 89.38%), respectively. Furthermore, M. obstructa was more sensitive to methomyl, copper sulfate including metaldehyde compared to the brown garden snail. So, the compounds were caused % mortality, for the glassy clover, that (96, 96 and 84 %) respectively, whereas percentage mortalities for the brown garden snail were (96.48, 76 and 71.42%) for methomyl, metaldehyde and copper sulfate, respectively. Moreover, there is not dissimilarity of sensitivity between examined snails to methomyl. Additionally, mortality for snails was increasing by time exposure for compounds. This investigation displayed, copper sulfate can use as a molluscicide for land snails at concentration of 20 × 10³ ppm, to give % mortality in a range of (55.17 – 96.0) %.