This work aims at throw light on the efficiency of Lufenuron (Owner 5%), diflubenzuron (Dimilin48%), Emamectin benzoate (Emafel4%) and Indoxacarb ( Strong 30%) on the 2^nd and 4^th larval instar of the cotton leaf warm,(Owner ) is the most potent insecticide against S. littoralis larvae ,which caused the shortest larval, pupal and adult durations being 11.26,10.80 and 6.33 days respectively. Current study was conducted on the insecticidal effect of Lufenuron on percentages of larval mortality (80%), pupation 20% and adult 53.7%. The tested dose level of all treatments showed highly histopathological disturbanecs in the midgut of this pest including distruction of the muscle layers, disorgarization in the epitheliul cells, separation of the peritrophic membrane as well as detachment of the basement membrane and appearance of vaculaizations . This observation might explain high mortality in treated larvae as compared to the control.