Pomegranate, Punica granatum L. (Punicaceae) fruits varieties (Baladi and Wonderful) were tested for their resistance and susceptibility to Mediterranean fruit fly, Ceratitis capitata (Wiedemann) and peach fruit fly, Bactrocera zonata (Saunders) infestation in choice and non-choice tests. P. granatum L. var. Baladi fruits were resistant to both C.capitata and B.zonata infestations in choice and non-choice tests. Host preference test proved that P.granatum L. var. Wonderful acted as a preferred host as guava fruits, Psidium guajava fruits for C. capitata and B. zonata. Egg-larval durations of C. capitata and B. zonata reared on P. granatum var. Wonderful fruits were longer than that reared on P.guajava fruits. Pupal durations of C.capitata and B.zonata produced from P.granatum L. var. Wonderful and P.guajava fruits varied insignificantly. The chemical analysis of P.granatum fruit peels proved variation in the polyphenolics amounts in both tested varieties. The amounts of total phenols, flavonoids and tannins in P.granatum var. Baladi were more than var. Wonderful. Fungal infection of the tested fruits affected the polyphenolics amounts in both tested varieties.