The present investigation was conducted at the apiary of Beekeeping Research Section at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate from September, 2007 until April, 2008. The objective was to find out the effect of mixing some supplements to the sugar syrup, offered to feeding the colonies, on honeybee activities and honey yield. The results indicated that the total number of workers foraging in treatments of thyroxine 1.6x10^-7M + melatonin 1.2%, thyroxine 1.6 x 10^-7 M, melatonin 1.2% and melatonin 1.2% + IKI 10 ppm were 128.00, 116.28, 104.79 and 98.85 workers/colony/minute, respectively. IKI 10 ppm and control treatments induced the lowest total number of workers foraging (76.10 and 78.85 worker/colony/minute, respectively). Increase percentages of brood rearing areas over the control were in treatment of thyroxine + melatonin (44.02%), thyroxine (36.79), melatonin (30.11) and melatonin + IKI (27.28 inch²/colony). The lowest one was that of IKI treatment (-1.96 inch²/colony). The lowest monthly average of stored pollen was recorded during November, 2007 in colonies fed on thyroxine + melatonin, thyroxine, melatonin, melatonin + IKI, IKI and control, with values of 37.40, 35.20, 33.20 30.10, 25.20 and 26.40 inch²/colony, respectively. The highest monthly averages of stored pollen area were recorded during March, 2008 for the same previous treatments recording 220.23, 210.80, 195.50, 190.50, 166.56 and 170.85 inch²/colony, respectively. Data proved that thyroxine + melatonin treatment gave the highest average of workers incoming with pollen followed by thyroxine, melatonin, then control, while IKI treatment recorded the lowest average. No significant differences in honey yield were found among colonies fed on thyroxine, melatonin and melatonin + IKI treatments.Only the treatment of thyroxine + melatonin overpassed the other treatments, which could be recommended to enhance the honeybee activities and honey yield.