Field trials were conducted during 2004-05 and 2005-06 seasons  at Motobis district, Kafr El-Sheikh Governorate to evaluate the efficiency of some post-emergence herbicides in controlling broadleaf and grassy weeds in wheat cv. Sakha 168 .The treatments included Brominal 24%  EC, Framinal 24% EC, Koril W 24% EC, Pardner22.5% EC, Proturon 50% SC, IPFlow 50% FL, Turinex 50% SC, Swat 50% SC, Tarok 71.4% WG, Granstar 75% DF, Granon 75% DF, Korestar 75% DF, Ecopart 2% SC and handweeding. The herbicides were applied at 2 and 4-leaf stages of wheat and handweeding was carried out twice at 20 and 40 days after sowing. Results showed that all weed control treatments significantly reduced weed fresh weights and increased grain yield of wheat.However, all tested herbicides gave higher weed control than handweeding . Morever, these herbicides provided better control at 2-leaf stage than at 4-leaf stage of wheat.       Results also indicated that the herbicides formulations could affect the herbicidal efficiency . Generally ,    Brominal, Framinal and Granstar achieved the best weed control treatments and gave maximum grain yield in the two tested seasons.