Fourdifferentchemical inducers for resistance and metalaxyl fungicide were tested to control sorghum downy mildew disease (Sorghum vulgare L.) caused by Peronosclerospora sorghi (Weston and Uppal) C.G. Shaw. This evaluation was conducted at Gemmeiza Agricultural Research Station, El-Gharbea Governorate, Egypt in 2006 and 2007 seasons. Combined data reveal that metalaxyl occupied the first rank in controlling the disease. Salicylic acid was  the best of the inducers in controlling sorghum downy mildew disease. While, potassium di-phosphate (K₂ Hpo₄) was the least effective one in this respect . Seedlings sprayed with salicylic acid gave the highest increase in 1000 grain weight in comparison with non-sprayed. In the same time spraying with salicylic acid and zinc sulphate increased grain sorghum leaves content of chlorophyll, nitrogen, protein and phosphorus. While potassium di-phosphat increased the leaves content of chlorophyll and potassium. Iron sulphate gave the lowest values in grain sorghum leaves content. The enzymatic activity of peroxidase and polyphenoloxidase and phenolic compounds contents in the grain sorghum leaves showed the highest values with salicylic acid and potassium di-phosphate followed by zinc sulphate . While iron sulphate gave the lowest values in this regard. No significant differences were obtained between metalaxl and the other compounds in the plant height and leaf area, while it showed the highest value in head length. However, metalayl followed by salicylic acid showed significant affect in increasing grain yield comparing with the other compounds. salicylic acid, potassium sulphate and metalaxyl showed  highest values in increasing activities of phenols and enzymes.