The cowpea aphid, Aphis crassivora (Koch) ( Homoptera : Aphididae)  one of the most important pests in Egypt. This work dealt with the laboratory and field tests of the effect of Biofly, Neemex and Sumithion compounds on the cowpea aphid and its parasitoids and predators. The laboratory tests indicated that the potency of Biofly, Neemex and Sumithion was varied tremendously due to compounds and also, data proved that at any of the compounds the higher the concentration, the higher was the rate of mortality and vice versa. The obtained results indicated that, when A. crassivora, the parasitoid Aphidus ervi Haliday (Hymenoptera:Aphididea), the predator, Chrysoperla carnea (Steph.) (Neuroptera: Chrysopidae) and Coccinella undecimpunctata L. (Coleoptera : Coccinellidae) were treated with Biofly, Neemex and Sumithion, the mortality percentages ranged from61.4-92.5, 59.7-89.7, and 89.5-100%.;  62.8-93.6,  61.2-91.9 and 91.8-100%;  61.5-91.3 ,59.6-88.6 and 89.7-100% and 59.8-92.7, 58.2-80.5 and 87.1-100%, respectively.  In the filed tests the results observed,  the two compounds Biofly and Neemex gave moderate effect against adults , nymphs of A. crassivora, C. undecimpunctata, C. carnea and A.ervi with percent reduction 68.1 & 74.3% and 64.43 & 71.87%  ; 68.2 & 78.66% and 68.70 & 75.8%  ;59.1 & 56.1%  and 60.3 & 58.2%; 57.2 & 63.8% and 58.3 & 68.4%  and  63.60 & 65.1% and 66.8 and 60.4 %   after 15 days, in the first and second years, respectively. On the other hand, Sumithion gave high efficacy against all targets, adult, nymphs of A. craccivora, C. undecimpunctata , C. carnea and A.ervi with percent reduction97.5 and 97.3 ; 96.8 and 96.6%;  94.6  and95.8 ;  96.7% and 95.6%   and  97.6%  and 98.7% after 15 days from application in the first and second years, respectively.