The efficacy of natural and chemical compounds were investigated against wax moth greater, Galleria mellonella L.and lesser, Acheroia gresilla Fab. . Spinosad and Bacillus thuringiensis (Agerin ) as natural compounds , while Formic acid, oxalic acid, Phostoxin, and Bara-dichlorobenzen were used as chemical compounds . The mortality percentage of wax moths dead larvae were 99.33, 90, 64 and 56.66 by using Phostoxin, PDB, Formic acid and Oxalic acid , respectively , while these mortality was 79.67 and 74.33 % when using Spinosad and Agiren . Results obtained in this study indicated that, the highly and lowest effecte was Phostoxin and Oxalic acid respectively against larvae of wax moths