The present work aims to use three concentrations (1, 2 and 3%) of Chloral hydrate adding to 4% Paraphenylenediamine (PPD) (Saudi, 2012) in order to improve of PPD against three rodent species: Norway rat, Rattus norvegicus, Nile grass rat, Arvicanthis niloticus andhouse mice, Mus musculus under laboratory conditions. The results showed a high rate of consumption of the bait when using with the low concentrations of Chloral hydrate. While the 4% PPD without additions were the first in bait consumption. Rodent females consumed high rate of baits as compared with males. The consumption were (45.60 and 63.60), (56.80 and 83.80), (21.20 and 32.20 g/animal) for males and females of Norway rat,  R. norvegicus, Nile grass rat,  A. niloticus and house mice, M. musculus respectively. Mean of consumed baits were: 48.43, 76.38 and 27.13 g/animal Norway rat, R. norvegicus, Nile grass rat, A. niloticus, andhouse mice, M. musculus respectively. The results also indicated that the period of stay alive of tasted animals increases gradually with an increasing of Chloral hydrate (carried on crushed maize) compared to using also control bait. Females were most durable and lasted the longest life comparative with males for all rodent species tested. These periods were (9.10 and 12.90), (8.00 and 11.85), (7.75 and 13.05 day) for Norway rat, R. norvegicus, Nile grass rat,  A. niloticus and house mice, M. musculus, respectively. Also Norway rat, R. norvegicus showed a longer period of survival than the other two species. On the other hand, the reduction in weight of the males of the three tasted rodent species was less than the reduction in weight of females when using Chloral hydrate concentrations carried on crushed maize.