The present study was carried out at Rice Research and TrainingCenter farm and Plant Pathology Department, Sakha, Kafr El-Sheikh, Egypt. During 2012 and 2013 successive seasons to screen and evaluate some exotic and local seven verities along with the best 13 selected lines developed from the diallel cross which done during 2006. selection was done from F2 up to F5. Screening testing was made for the 20 rice genotypes against the major diseases infesting rice in Egypt such as, blast, brown spot, bakanae and white tip nematode diseases. Randomized complete block design with three replicates was used under field condition to estimate yield and its attributes as well as the reaction of the different studied diseases. Twenty entries/genotypes were tested under greenhouse and field conditions. Results indicated that, SP- 70, IRAT 112, IR 65610-105-2-5-2-2-2, GZ 7769-2-1-1-2, SK-101-7-16, SK-101-7-17, SK-101-7-25, SK-101-7-26, SK-101-7-35, SK-101-7-37, GG-46-6-1, SK-101-Pa-1, SK-101-Pa-3 and SK-101-Pa-4 were resistant to all rice blast races under this study. On the other hand, GG-24-1-2 and GG-42-2-6 genotypes were susceptible to one race, while GG-24-1-2 showed moderate resistance for the two races. For brown spot results indicted that, HR 4856, IRAT 112, SK-101-Pa-1and Sakha 101 gave the highest infection percent and  severity. On the other hand, GG-46-6-1, SK-101-7-26, GG-42-1-2 and SK-101-7-35 gave the lowest infection percent and severity. For bakanae disease, Sakha 101 as a susceptible cultivar gave the highest percentage and severity infection values of 76.08 and 18.66 % respectively, followed by GZ 7769 and Sakha 104 (65.74, 15.33 % and 47.57, 13.15 % respectively). On the other hand, all entries gave the lowest infection of bakanae rice disease under natural infection. For white tip nematode, the genotypes of GZ 7769, HR 4856, Sakha 104, SK-101-Pa-3, Sakha 101 and SK-101-7-26 gave the highest infection. While the genotypes, SP-7, SK-101-7-16, SK-101-7-17,  SK-101-7-35, SK-101-7-37, GG-42-6-1, GG-42-1-2, GG-42-1-6 and SK-101-Pa-4 gave the lowest infection values. For Vitavax as recommended fungicide to control rice Bakanae disease and sodium chloride treatment were the highest efficiency to control the bakanae disease under natural and inoculated conditions. Results show that some genotypes could be used i.e. SP-70 and SK 101-7-16 and SK 101-7-17 and SK 101-7-35 and SK 101-7-37 and GG-46-6-1 and GG 42 - 1-2 and GG 42-1-6 and SK 101-Pa-4 as the sources of diseases resistance in rice breeding programs.