The present study was designed to determine the effect of seven chemicals used to control mange mite on sheep. These chemicals were (1) Mange cides 10%, (2) Tincture idone 4%, (3) Noromectin 1.0% used once a month, (4) Noromectin 1.0% used twice a month, (5) Mange cides + skin recovery, (5) Noromectin 1.0% injection + Mange cides and (7) Mange cides + skin recovery + Noromectin 1.0% treated twice a month. Sheep infected with scabies were responded to the healing of the disease when treated with the compounds mentioned above (i.e., Mange cide 10%; Tincture idone 4%; Norometcin 1.0% once a month and Noromectin 1.0% twice a month) are just 45, 45, 30, and 20 days, respectively.