This study was conducted to evaluate the physiological and biochemical changes, [glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), total soluble protein (TSP), lipid peroxidation (MDA) and protein carbonyl content (PCC)] in haemolymph of mulberry silkworm Bombyx mori larvae were reared on mulberry leaves treated with camphor honey and oil as a nutritional additives in the 4^th and 5^th instars with five concentrations. Results showed that at 4% & 5% concentrations of honey and 1% & 2% concentrations of oil exhibited the best results compared with control; larvae reared on leaves enriched with these concentrations of honey and oil showed a significant increase in GPT, GOT and TSP means and a significant decrease in free radicals (MDA & PCC) means compared with control.