Field experiments were conducted at Sakha Agricultural Research Station Farm during 2011 and 2012 cotton growing seasons to evaluate the efficacy commercial formulation of four insecticides, i.e., pyridalyl, emamectin benzoate, methomyl and methoxyfenozide against pink bollworm, Pectinophora gossypiella (Saund.) and spiny bollworm, Earias insulana (Boisd.). Pyridalyl and emamectin benzoate were the most efficient compounds during the two seasons. The treatments could be arranged descendingly according to the average reduction of two seasons as follows: pyridalyl (52.21, 50.78 %), emamectin benzoate (46.55, 49.61%), methomyl (38.49, 37.82 %) and methoxyfenozide (34.10, 31.90 %) against pink and spiny bollworms. Also, the toxicity of these compounds was determined against 4^th instar larvae of spiny bollworm, E. insulana (Boisd.) using film residue assay method. The data revealed that emamectin benzoate was a superior potent compound followed by methoxyfenozide, pyridalyl and methomyl, with LC₅₀ values were 1.42, 14.21, 16.99 and 99.78 ppm, respectively.