The effect of certain insecticides (Agrinate, Vertimic and Actara) and biocides (Zantara, Biovar and Bioranza) were studied at Sharkia Governorate during the growing seasons 2011and 2012. Results revealed that Agrinate was the highest mortality percentages against M. cartusiana, snails, while Actara noticed the lowest one where mortality percentages reached 86.33 and 11.0%, respectively under laboratory conditions. Under field conditions, it was noticed that Agrinate more effective than any insecticides or biocides where reduction percentage reached 77.17% while biovar gave 15.98%.Generally, Agrinate was highly efficiency against M. cartusiana (Müller) snails under laboratory and field conditions.