Shot-hole on leaves of stone fruit, caused by Stigmina carpophila (Lev.) M.B. Ellis was serious on  peach, apricot and plum trees in Nobariya area, 6-^th October and Menofiya governorates in 2007-2008 seasons. Isolation carried out from different cultivars revealed no variation among isolates from samples collected from different localities. Calcium and potassium salts (chloride and hydroxide) were more effective than (nitrate and phosphate) in reduction of S. carpophila in the In-vitro and open filed, Higher efficacy of salts to control shot hole disease was recorded for the higher salt concentration as shown in trees sprayed with 1800 ppm.  Antagonism studies done on the pathogen and bioagents i.e. Trichoderma viride, T. harzainum, B.light stop (T. harzainum), and Bacillus subtilis either in In-vitro or in greenhouse reduced disease severity in both 2007 and 2008 seasons.  Fungicides tested i.e. (Punch, Sumi-8, Sythane-24, Topas-100, Flint, and Cam Zen) in the In-vitro and in open field gave the best control of shot hole disease.