The contamination of the aquatic environment and the marine organisms with trace elements and the other contaminants have been of considerable interest. The present study is related to monitoring of trace elements (cadmium (Cd), lead (Pb) and mercury (Hg) and organochlorine pesticides as well as polychlorinated biphenyls (PCB) concentrations in fish tissues of different species collected from different Egyptian governorates. A total of seventy one samples of different fish species were subjected to heavy metals analysis for mercury, cadmium, and lead investigation. However, only thirty five samples were analyzed for eighteen chlorinated pesticides and seven polychlorinated biphenyl (PCB) congeners. In heavy metals analysis, the results showed that only 12.7% of the samples were free from any detectable amount of Cd. However, 87.3% of the total number of fish samples analyzed was contaminated with Cd element, of which 7 % exceeded the maximum limits established for Cd by EU (2007) and EOS (2009). The concentration levels ranged from 0.005 to 0.091    mg/kg and the violated samples were Barbony, Denise, saraghieus, Morgan and Sopeet. Data showed that 91.3% of all tested samples were contaminated with mercury. The concentration levels varied from 0.03 to 1.4   mg/kg. Also, data demonstrated that 8.7% of all tested samples had levels of mercury exceeded the established ML's for Hg. Morgan fish recorded the most violated samples (3 samples exceeded ML of Hg), while the lowest were Mousa and Wakar samples. Data showed that lead recorded the lowest contamination percentage (i.e. 77.1%). The concentration range varied from 0.03 to 1.8 mg/kg. Also, results showed that 4.2% of all tested samples containing lead levels exceeded the ML of Pb. The violated samples were Denis, Loot and Wakar. In the residues analysis of pesticide and PCB's, results showed that total contamination of fish by organochlorine pesticides (DDE p,p and DDD p,p) and PCBs were 57% and 37%, respectively. It was noticed that 14.3% from the total of samples analyzed were contaminated with detectable levels (i.e. more than LOQ) of organochlorine pesticide residues, in concentration levels ranged from 0.005 to 0.04 (mg/kg), Results showed that the percentage of   the  violation was 54.3%.  The violated samples were Bory, Bolty, and Karameet. Data showed that the highest contamination percentage with DDEp,p recorded in Bory samples (i.e. 26%), followed by Bolty (i.e. 11.4%) and the lowest in Karameet fish samples (i.e. 8.6%).However,   8.5% from total number of  samples were contaminated with  DDD p,p  less than LOQ (0.05 mg/kg)  Also, results showed that all Karameet samples were contaminated with PCBs (28, 52, 101, 118, and 180), in concentration levels less than LOQ. On the other hand 14% of all analyzed Bolty samples were contaminated traces of PCBs (101,118,138,153 and 180). However, 71% of all analyzed Bory fish samples contaminated with detectable levels of PCBs (101,118,138,153 and 180), no exceeding of the levels of detected PCBs above the established MRL's.