Diamond back moth Plutella xylostella (Linn.), is the most destructive and regular pest of cabbage and cauliflower universally. Protection of crucifer crops from damage often requires application of insecticide to plant foliage, sometimes as frequently as twice per week. However, resistance to insecticides is widespread, and includes most classes of insecticides. Therefore, the studies were carried out to monitor their resistance factor form two region Kalubia and Menufia against seventeen insecticides having different mode of actions to develop strategies for its management. Results show that Menufia and Kalubia were susceptible to IGRs and pyrethroids except for pymetrozine in kalubia. Spinosad in Menufia was 108.54 folds and considered the higher levels of resistance attained, followed by prothiophos, abamectin and imidacloprid, 17.69, 26.18, 11.43, folds respectively. But in kalubia the higher folds of resistance was thiocyclam 42.24 followed by methomyl 20.96 folds.