Two field experiments were conducted in Tegzerte, Siwa Research Station, Desert Research Center during summer seasonns of 2003 and 2004 to study the influence of combinations of interrow tillage (tilled or none), row width (35 or 70cm.), cover crops (Medicago sativa or Sorghum bicolor)  and herbicide (Glyphosate or none) on Zea mays weed control and yield of maize.  Post emergence Glyphosate-resistant Zea mays applied at the seven-to eight-leaf maize growth stage as a post emergence. The experimental design was a randomized complete block with 20 treatments and three replications. The sequencing process of interrow tillage, narrow rows and Medicago sativa cover crop are the preferable practices that were used in maize early season weed suppression prior to the post-emergence Glyphosate application. In the case ofindividual factorwas the cover crops followed by interrow tillage. The best impact of marital factor in this case was the combination between interrow tillage and Medicago sativa cover crop. Best result, occurred at treatment combinations in the late season weed control was combining between Glyphosate herbicide, narrow rows and interrow tillage. In the case of individual and marital factor were Glyphosate and combination between Glyphosate plus narrow rows are the best, respectively.    Interrow tillage, narrow rows, Medicago sativa cover crop and Glyphosate herbicide are important weed management practices that can be integrated into full Z. mays production season.