Efficacy of imported and local entomopathogenic nematodes (EPNs) alone or in combinations with the insecticides, imidacloprid, zeta-cypermethrin, profenfos and emmectin benzoate against red palm weevil (RPW), Rhynchophorus ferrugineus differed greatly according to nematode species and instar larvae under laboratory conditions.Both Heterorhabditis bacteriophora (HP88 strain) and local species H.bacteriophora (Ar-4 strain) showed promising results by killing 92.20 and 82.13 % of the 4^th instar larvae after 9 days of exposure, respectively. Whereas, S. feltiae and H. bacteriophora (Ht strain) showed less insecticidal activity against 4^th, 9^th and 11^th instar larvae. On the other hand, Egyptian H. bacteriophora (Ar-4 strain) was more effective than H.bacteriophora (Ht strain). Adults of R. ferrugineus were less susceptible to nematode infection than instar larvae. According to LD ₅₀ with LT ₅₀ values, H. bacteriophora (HP88 strain) was more aggressive killer to RPW than native strains and LT₅₀ values were 5.693, 4.319 and 2.943 days at concentrations of 500, 1500 and 2500IJs/ml, respectively. At the LC₅₀ and LC₉₀ values, imidacloprid was the most toxic for 9^th and 11^th Instars of  R. ferrugineus, whereas, profenfos was the least effective one after 24 hr of exposure. The joint action of chemical pesticides with IJs of EPNs in controlling the 9^th and 11^th instar larvae of R.  ferrugineus showed an additive or potentiation reaction with no evidence of antagonistic action.Overall, results indicate the feasibility of an integrated use of these nematode species and chemical pesticides in controlling red palm weevil under field conditions.