A field study was conducted to compare the efficiency of the biocides, insecticides and insect growth regulators (IGR's) against cotton leafworm Spodoptera littoralis, whereas the results appeared that Virust was the most effective compound as it recording 63.64% reduction in the initial kill after five days achieved. Followed by Agerin and Brofect this gave 51.61, 46.38% reduction. While, Protecto was the least efficient compound, as it gave 27.14% reduction only. but about insecticides as lannate and Cord in eleven days after treatment it have a high efficiency in reduction (100%), while Flaxe was the lowest effective one which revealed 83.08 % reduction. On the other hand IGR'S, Toporon and Runner were gave (88.87 and 88.44 % reduction) and Demelin was the lowest effective (63.12 % reduction) after one day of treatment. As for the residual effect also Runner, Toporon, Virtue, keleron and Nomolt induced the best results, recording 100, 99.28, 99.08, 97.57 and 97.47 reduction percentages, respectively. Whereas, Demelin was the lowest effective one, which revealed 87.46% reduction during the period from 10^th to 15^th days after sprays application in the first season. While, in the second season Runner, Nomolt, Coragen and Virtue were the most effective insecticides they caused 85.73, 77.65, 77.17 and 73.01 % reduction, after five days of  spraying (initial kill), respectively. On the   other hand, Demelin and Diberone induced a low residual effect, where it showed only 89.49 % and 86.65 % reduction after 15 days of treatment.