Gibberellic acid(GA₃) and Indole acetic acid (IAA) is an endogenous plant growth regulator used world wide in agriculture ;however, little is known about its biochemical and physiological effects on mammals. This study investigated possible toxic and teratogenic effects of GA₃ and IAA on the embryo of albino rats. Female Wistar rats were given daily 200 ppm / 0.2 ml saline from either GA₃ or IAA orally from the 1st day of pregnancy until the 14^th, 16^th, or after delivery. Toxicity was demonstrated by a significant increase in malondialdehyde level and a decrease in the antioxidant enzyme activities of catalase, superoxide dismutase, and glutathione peroxidase in the brain, spinal cord, eye, and liver of pups. A significant decline of glutathione content was also observed. The biochemical parameters were correlated histologically with an abnormal development of the external morphology and formation of the skeleton of either GA₃ or IAA-treated pups.