Laboratory studies were conducted for evaluate the effect of Dipel 2×, (Bacillus thuringiensis Kurstaki) against pink bollworm Pectinophora gossypiella (Saund.),and Biover® (Beauveria bassiana) (Balsamo) against spiny bollworm, Earias insulana (Boisd.).The accumulated mortalities of both pink bollworm, Pectinophora gossypiella and spiny bollworm, Earias insulana larvae, after six days of treatment, were represented as the acute toxicity were, Dipel 2× attained 17.18±0.63 % larval mortality at 32×10⁶IU concentration against P. gossypiella larvae while Biover® resulted in 15.55±0.59% larval mortality against Earias insulana larvae comparing with 0.00% larval mortality in untreated check. At the  same time the tested biocide Btk (Dipel 2×)  caused different influences on all biological aspects of pink bollworm which decreasing larval duration, pupal weight, pupation percentage, adult emergence, oviposition periods, adult longevity, female fecundity decreased strongly which recorded 149.75±5.23 egg/female comparing with that 362.00±2.31 egg/female in untreated check. The tested biocide Btk (Dipel 2×) also decreasing hatchability percentage that exhibited 73.16±1.15 % as compared with 88.09±0.57 % that achieved in untreated check. Also, results cleared that the effect of Biover® fungi attained decreasing in all biological aspects, except the male and female longevity and oviposition periods compared with untreated check. Female fecundity was moderately influenced when spiny bollworm larvae treated by Biover® that achieved 60.33±11.66 eggs compared with 78.33±5.78 eggs laid /female deposited by check females.  Hatchability percentage of spiny bollworm also decreased vigorously which attained 41.12±6.45% as compared with that 82.33±7.51% in untreated once.