Impact of certain insecticides and their mixtures (emamectin benzoate, imidaclopride, chlorfenapyr, indoxacarb, profenofos, pyridalyl, methomyl, teflubenzuron) were evaluated against tomato leaf miner, Tuta absoluta (Meyrick) and Helicoverpa armigera (Hubner) populations on tomato crop at south valley region. LC₅₀ values indicated that emamectin benzoate was the most toxic compound (LC₅₀ 0.461 %) against T. absoluta, larvae. The carbamate insecticide, methomyl showed almost similar toxicity followed by in a descending order while teflubenzuron and chlorfenapyr were less effective (LC₅₀ 1.054 and 3.165 %), respectively. Pyridalyl was found to be the most effective insecticide against H. armigera. (LC₅₀ 0.513 %). The corresponding toxicities of the other tested insecticides, arranged according to their LC₅₀'s in descending order were as follow: methomyl, emamectin benzoate, profenofos, imidaclopride, teflubenzuron, indoxacarb and chlorfenapyr. The LC₅₀'s were ranged between (0.513 and 0.872 %), while, their toxicity indexes were ranged between (92.432 and 58.830 %). On the other hand, there were no differences occurred among the treatments. Mean of percent infestation were decreased 6 weeks after six sprayings, and the percent reduction in infestation were 79.73, 80.22, 78.41, 80.88, 80.50, 78.30, 79.64 and 78.25 % by using emamectin benzoate, methomyl, imidaclopride, pyridalyl, profenofos, indoxacarb, teflubenzuron and chlorfenapyr, respectively. The efficiency of the tested insecticides was increased with increasing the number of sprays from 2 to 6 causing reduction in insect leaf miner infestation ranged between 68.02 to 80.88 %, respectively. Generally, the tested insecticides and their mixtures achieved a considerable reduction in T. absoluta and H. armigera population.