The present research work aimed to evaluate the efficacy of five different products, two biocides (abamectin and protecto), two synthetic chemical products (methomyl and chlorpyrifos) and one mineral oil (Kz-oil) against some piercing-sucking insect pests attacking cotton plants and their side effects on the associated predators. The experiment was conducted during 2017 season at Kafr ElShenhab village, Mansoura district by using cotton variety Giza 94. From results were obtained, it is obvious that methomyl and chlorpyrifos were more effective as initial kill (72.2 and 68.2%), (66.4 and 51.9%) and (60.1 and 78.9%) for aphid, whitefly and predators respectively. But Kz-oil (61.4%) and abamectin (62.9%) were more effective against jassid and spider mites respectively as initial kill% (after 24 hrs. of treatment) effect, whereas a moderate or less initial kill effect ranged from 32.7 to 51.9% was recorded for the other products. In contrast, abamectin, protecto and Kz-oil were more safety against associated predators as initial kill as follows: 12.2, 9.5 and 12.5% respectively. With respect of residual mean and general mean effect, abamectin, protecto and Kz-oil were relatively highly effective against aphids (65.0, 63.3 and 61.6%) as residual mean and (61.8, 60.4,and 59.5%) as general mean effect and against jassids by moderate effect (50.3, 51.4 and 57.7%) as residual mean and (48.7, 48.3 and 58.3%) as general mean effect respectively. While other tested products recorded a weak effect as residual mean and general mean effect against all piercing sucking insects except both methomyl and chlorpyrifos were highly effective against predators (78.0 and 48.9%) and (75.0 and 53.9%) as residual mean and general mean effect respectively.