Brown snails (Eobania vermiculata), one of the most abundant gastropod of Egyptian farms, which causes many damages for economic crops and ornamentals plants. Methomyl, pirimicarb, and oxamyl as a symbol of carbamates pesticides group, malathion as a symbol of organophosphates pesticides group, thiamethoxam, imidachloprid, and acetamiprid as a neonicotinoid pesticides group symbol, lambda-cyhalothrin as a pyrethroid pesticides group symbol, pymetrozine as a symbol of Antifeedant pesticides group, and the symbols of fungicide pesticides group were carbandazim, and copper sulfatewere used against snails, by baiting techniques. Bioassay results showed high activity of methomyl, oxamyl, acetamiprid and lambda-cyhalothrin against E. vermiculata., all over the different times of exposure, after 24 hrs the LC₅₀ values were = 0.259, o.358, 1.049 and 5.976 % respectively, the LC₅₀ values after 48 hrs were = 0.058, 0.90, 0.37 and 0.305 % respectively, the LC₅₀ values after 72 hrs = 0.024, 0.023, 0.129 and
0.187 % respectively, and the LC₅₀ values after    96 hrs = 0.024, 0.004, 0.039 and 0.047 % respectively. Biochemical studies of the four mentioned pesticides showed significantly inhibition effect for snail enzymes: acetylcholinestrase (AChE), carboxyl esterase (CaE), catalase, glutathione-s-transferase (GST) and polyphenoloxidase (PPO).  So, these pesticides is promising as a new identification as molluscicides, available in the markets with suitable prices for users, instead of classical molluscicides, which became rarely in the markets and very expensive.