Three field trials were conducted to evaluate three entomopathogens (Metarhizium acridum, Beauveria bassiana and Nosema locustae) and two chemical insecticides (Indoxacarb and Fipronil) against berseem grasshoppers Euprepocnemis plorans (Charp.). Results from the first trial indicated that both M. acridum and N. locustae are successful pathogens against grasshoppers in the field but their effect was slow, while both Indoxacarb and Fipronil are effective insecticides aginst E. plorans in the field when used as spray or bait techniques. Moreover, results from second trial showed that mixtures of M. acridum with low dose (10% of recommended dose) of Indoxacarb and Fipronil caused acceleration in grasshopper mortality when used as spray technique. In the third trial the obtained results showed that N. locustae mixtures with Indoxacarb and Fipronil also caused acceleration in grasshopper's mortality. It could be concluded that using M. acridum and N. locustae in combination with low dose (10% of recommended dose) of Indoxacarb and Fipronil could achieve environmentally safe control operation, moreover Indoxacarb and Fipronil could be used in grasshoppers control as new group of insecticides in replacement of classical groups of insecticides.