Toxicity of certain insecticides Emamectin benzoate (E) IGRs, Diflorate (D) 25%, Grand (G) 5% EC, mineral oil KZ oil (KZ) and plant oil Garlic oil (GO) were tested against strain producer laboratory of 4^th larvae instar of Spodoptera littoralis (Boisd) The LC₅₀, LC₂₅ and LC₁₀ were calculated for all treatments. The mixtures results may be arrangement in categories as following; 1. Mixtures showed that highest potential action by the lowest concentration of LC₂₅+ LC₁₀ (E+D), LC₂₅+ LC₁₀ (E+ G), LC₁₀+ LC₂₅ (E+ G), LC₂₅+ LC₁₀ (E+ Kz), LC₁₀+ LC₂₅ (D+ G), LC₁₀+ LC₂₅ (D+ Kz), LC₁₀+ LC₁₀ (G+ G) and LC₁₀+ LC₂₅ (G+ Kz); 2. Mixtures revealed that antagonism action LC₁₀+ LC₅₀ (E+ D), LC₁₀+ LC₂₅ (E+ G), LC₁₀+ LC₅₀ (E+ Kz), LC₂₅+ LC₅₀ (G+ G) and LC₂₅+ LC₅₀ (G+ Kz); 3. Mixtures cleared that additive effective LC₂₅+ LC₅₀ (E+ D), LC₅₀+ LC₁₀ (E+ G), LC₂₅+ LC₂₅ (E+ G), LC₅₀+ LC₅₀ (E+ Kz), LC₅₀+ LC₂₅ (D+ G), LC₂₅+ LC₂₅ (G+ G) and LC₅₀+ LC₂₅ (G+ Kz) though, use IGRs, plant or mineral oils, compounds in binamy as a mixture with little concentrations, it has been shown to be effective in controlling of S. littoralis.