Field experiments were carried out at El-Ghorieb village, Sahel Selem district, Assiut Governorate during two growing successive seasons, 2013 and 2014 to study some ecological aspects of some piercing sucking pests and associated natural enemies inhabiting water melon, Citrullus vulgaris (Schard). Results indicated that the major piercing sucking pests [the two-spotted spider mite, Tetranychus urticae Koch; the whitefly, Bemisia tabaci (Genn.); the cotton aphid, Aphis gossypii Glover and the leafhopper, Empoasca decipiens (Paoli)] and their associated natural enemies [Coccinella undecimpunctata, Chrysopa carnea, Orius sp. and Scolothrips longicornis] Data showed that the relation between the natural enemies with their preys was positively and significantly during both seasons. The results also showed that the highest dominance and abundance were recorded with the piercing sucking pests; T. urticae and B. tabaci followed by E. decipiens and A. gossypii as for the natural enemies; S. longicornis followed by Orius sp., C. undecimpunctata and Ch. Carnea. Finally, the previous natural enemies could have a promising role when planning Integrated Pest Management (I.P.M.) strategies with other safe methods to protect the surrounding environment from pollution.